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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human duodenal mucosa from healthy subjects after treatment with the non-steroidal anti-inflammatory drug idomethacin or a placebo

ABSTRACT: Indomethacin is a non-steroidal anti-inflammatory drug. It is widely used in clinical practice. In scientific intervention studies, it is applied as a methodology to inflict reversible damage to gastrointestinal epithelium. The exact pathogenesis is not well understood. The present study aimed to obtain a better understanding of indomathacin-induced pathogenesis by determining its effects on gene expression in duodenal mucosa in healthy subjects. Tissue samples from the horizontal part of the duodenum were obtained by standard flexible gastroduodenoscopy, and Affymetrix microarrays were used to determine genome-wide gene expression profiles.

ORGANISM(S): Homo sapiens

SUBMITTER: Freddy Troost

PROVIDER: E-MEXP-1337 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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