Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age.

ABSTRACT: Microarray comparison of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age. RNA was extracted from substantia nigral cells that were isolated by laser capture microdissection.

INSTRUMENT(S): other

ORGANISM(S): Mus musculus

SUBMITTER: Talene Yacoubian

PROVIDER: E-MEXP-1383 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional dysregulation in a transgenic model of Parkinson disease.

Yacoubian Talene A TA Cantuti-Castelvetri Ippolita I Bouzou Bérengère B Asteris Georgios G McLean Pamela J PJ Hyman Bradley T BT Standaert David G DG

Neurobiology of disease 20071128 3

Alpha-synuclein has been implicated in Parkinson disease, yet the mechanism by which alpha-synuclein causes cell injury is not understood. Using a transgenic mouse model, we evaluated the effect of alpha-synuclein overexpression on gene expression in the substantia nigra. Nigral mRNA from wild type and alpha-synuclein transgenic mice was analyzed using Affymetrix gene arrays. At 3 months, before pathological changes are apparent, we observed modest alterations in gene expression. However, nearly ...[more]

PMID: 18191405

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Dataset Information

Transcription profiling of transgenic mice overexpressing human alpha-synuclein under the PDGF beta promoter to wildtype littermates at 3 months and 9 months of age.

Publications

Transcriptional dysregulation in a transgenic model of Parkinson disease.

Similar Datasets

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