Transcription profiling time series of rat retina after intra-orbital nerve transection, intra-orbital nerve crush or no treatment

ABSTRACT: Array experiment: Animals were divided into a control group (naive), which did not undergo any experimental manipulation (n=20) and two experimental groups, one receiving an intra-orbital nerve transection (IONT, n=60) and the other an intra-orbital nerve crush (IONC, n=60) Sterile precautions were maintained for all surgical procedures. The left ON was intraorbitally axotomized according to procedures that are standard in our laboratory. (REF) Briefly, an incision was made in the superior orbital rim, the superoexternal orbital contents were dissected, and the superior and external rectus muscles were removed. When performing IONT, the dura mater was opened longitudinally to spare the blood supply, and the optic nerve was transected 0.5 mm from the optic disc. To perform IONC the optic ne

ORGANISM(S): Rattus norvegicus

SUBMITTER: Marta Agudo 

PROVIDER: E-MEXP-1387 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress