Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

9 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNAi knock down of QKI in human astrocyte glioma cells shows that QKI depletion affects expression of immune response-related genes

ABSTRACT: We studied the effect of small interfering RNA (siRNA)-mediated QKI depletion on global gene expression in human oligodendroglioma cells and astrocyte glioma cells

INSTRUMENT(S): GenePix Personal 4100A [Axon Instruments]

ORGANISM(S): Homo sapiens

SUBMITTER: Lin Jiang

PROVIDER: E-MEXP-1393 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of occipital cortex tissue from male and female humans, macaques and marmosets to investigate sex differences in primate brain

Project description:We compared gene expression patterns between the occipital cortex tissues of four male and four female individuals in three species: an ape (human, Homo sapiens), an Old World monkey (macaque; Macaca fascicularis), and a New World monkey (marmoset; Callithrix jacchus). To do so, we hybridized cDNA from each sample (n = 24) to a human cDNA microarray that contains 46,128 probes. (Human 46k cDNA, http://www.biotech.kth.se/molbio/microarray/). We used a loop hybridization study design restricted to within-species comparisons only, in which we co-hybridized on each slide samples from the opposite sex.

2008-03-01 | E-MEXP-1182 | biostudies-arrayexpress

Transcription profiling of brain samples from human control and schizophrenia patients who were treated with either typical, atypical or no antipsychotic medication

Project description:Multiple studies have shown that brain gene expression is disturbed in subjects suffering from schizophrenia. However, disentangling disease effects from alterations caused by neuroleptics is a challenging task. <br> To address the issues of disease heterogeneity and the effect of antipsychotic medication, we use a large collection of 110 brain autopsy samples, subdivided according to the type of antipsychotic medication received. We use global and high-resolution mRNA quantification techniques to analyse gene expression in brain tissues. We also analyse transcription in-vitro, in cell lines before and after treatment with cytokines.<br> Results. We show that inflammation-related genes are up regulated in all groups of patients, including those not treated at the time of death. In particular, four co-expressed genes that are inducible by inflammatory cytokines showed increased mRNA levels, namely IFITM2, IFITM3, SERPINA3, and GBP1 (p-values from qPCR ? 0.01). We also show that these genes are expressed in oligodendrocyte and endothelial cell lines, and transcription is inducible by inflammatory cytokines in both cell lines. Our results give molecular support to the inflammatory theory of schizophrenia and suggest that inflammatory cytokines may stimulate transcription in endothelial brain cells during schizophrenia progression. Unexpectedly, inflammation-related genes may also have a role in myelin producing cells, since they are also inducible by cytokines in oligodendrocyte cell lines. Our findings encourage future research to explore whether anti-inflammatory agents can be used in combination with traditional antipsychotics for a more efficient treatment of schizophrenia.

2007-12-06 | E-MEXP-857 | biostudies-arrayexpress

Transcription profiling of silver fox brain selected for tame behavior vs non-selected silver fox

Project description:Comparison of brain gene expression between silver foxes selected for tame behavior and non-selected silver fox.

2005-12-31 | E-MEXP-451 | biostudies-arrayexpress

Transcription profiling of brain from homozygous narcoleptic dogs and their heterozygous unaffected siblings

Project description:Brain gene expression profiles of homozygous narcoleptic dogs and their heterozygous unaffected siblings

2007-09-27 | E-MEXP-1076 | biostudies-arrayexpress

miRNA array of 5 plasma with recurrent stage II gastric cancer against 5 plasma non-recurrent stage III gastric cancer in humans

Project description:1ml plasma from 10 age- and sex-matched patients (GC stage II with recurrence: sample number 1-5; and stage III without recurrence: sample number 6-10) were arrayed for differential expressed miRNAs so as to look for miRNAs that were associated with GC recurrence. Raw CT values were shown in this dataset.

2017-08-18 | E-MTAB-5854 | biostudies-arrayexpress

Transcription profiling of wild type and rcd3-1 mutant Arabidospsi plants

Project description:Three week old Arabidopsis thaliana wildtype (Col-0) was compared with the rcd3-1 mutant.

2008-01-09 | E-MEXP-1388 | biostudies-arrayexpress

Transcription profiling of synchronized Sulfolobus acidocaldarius populations as they progress through the cell cycle

Project description:Exponentially growing Sulfolobus acidocaldarius were treated with NaAc to generate replication runout and arrest in G2 phase. The cells were then resuspended in fresh acetate-free media which generates a synchronous population. Samples for investigation of gene expression change were taken during the synchronised populations progress through the cell cycle.

2007-12-08 | E-MEXP-936 | biostudies-arrayexpress

Transcription profiling of Arabidopsis wild type and rcd1-1, rcd1-3, rcd1-4 and sro1-1 mutants

Project description:Control (Col-0) and mutants (rcd1-1, rcd1-3, rcd1-4 and sro1-1) were grown for 22 days under control conditions. Whole rosettas were harvested and analyzed for changes in gene expression between Col-0 and the mutants.

2008-12-12 | E-MEXP-1949 | biostudies-arrayexpress

Effects of deletion of the scw1 RNA-binding proteins on RNA stability using an in vivo labelling system to estimate the decay rates of scw1 mutants and wild type S. pombe cells

Project description:To investigate the contribution of the scw1 RNA-binding protein to the regulation of RNA decay we used an in vivo labelling system (Cleary et al. 2005 Nat Biotechnol. 23, 232-7) to estimate the decay rates of scw1 mutants and wild type S. pombe cells

2014-11-06 | E-MTAB-2317 | biostudies-arrayexpress

Transcription profiling of hyperthermophilic crenarchaea Sulfolobus solfataricus and Sulfolobus acidocaldarius to UV irradiation

Project description:Analysis of transcriptional response to UV irradiation in two related crenarchaea, Sulfolobus solfataricus and Sulfolobus acidocaldarius.

2007-11-21 | E-MEXP-1252 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data