Transcription profiling of acute telomere dysfunction in the mouse liver using adenoviral mediated, transient expression of a dominant negative version of TRF

ABSTRACT: Telomere dysfunction induces two types of cellular responses: cellular senescence and apoptosis. Here we analyzed the influence of the cellular level of telomere dysfunction and the role of p53 on induction of apoptosis and senescence in mouse liver using the experimental system of adenoviral mediated, transient expression of a dominant negative version of TRF2 (TRF2DBDM). Gene-profiling experiments identified p53-dependent and p53-independent changes in gene expression in response to telomere deprotection and transcription factors potentially regulating these genes.

ORGANISM(S): Mus musculus

SUBMITTER: Michael Manns 

PROVIDER: E-MEXP-141 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress