Transcription profiling of hepatocyes from Zucker fa/fa obese rats vs controls

ABSTRACT: Analysis of the gene signature of steatosis associated to obesity in hepatocytes of Zucker fa/fa obese rats and their controls; identifying target genes linked to steatosis progression. or Obesity and insulin resistance-associated steatosis can be a non-inflammatory condition affecting hepatocytes or progress to steatohepatitis: a condition that can result in end-stage liver disease. Although molecular events leading to accumulation of lipid droplets in the liver have been identified individually, the complexity of the condition suggested that emergent target would be uncovered by a more comprehensive examination. Then, this study was aimed at establishing a gene signature of steatosis in hepatocytes and at identifying target genes linked to steatosis progression. Using Affymetrix oligonuc

ORGANISM(S): Rattus norvegicus

DISEASE(S): normal

SUBMITTER: Xabier Buqué 

PROVIDER: E-MEXP-1414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress