Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of hepatocyes from Zucker fa/fa obese rats vs controls

ABSTRACT: Analysis of the gene signature of steatosis associated to obesity in hepatocytes of Zucker fa/fa obese rats and their controls; identifying target genes linked to steatosis progression. or Obesity and insulin resistance-associated steatosis can be a non-inflammatory condition affecting hepatocytes or progress to steatohepatitis: a condition that can result in end-stage liver disease. Although molecular events leading to accumulation of lipid droplets in the liver have been identified individually, the complexity of the condition suggested that emergent target would be uncovered by a more comprehensive examination. Then, this study was aimed at establishing a gene signature of steatosis in hepatocytes and at identifying target genes linked to steatosis progression. Using Affymetrix oligonucleotide arrays, we compared transcriptomes of hepatocytes isolated from Zucker "fa/fa" obese rats with three different age-related grades of steatosis with those of their counterpart non-steatotic cells.

ORGANISM(S): Rattus norvegicus

SUBMITTER: Xabier Buqué 

PROVIDER: E-MEXP-1414 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats.

Buqué Xabier X   Martínez María José MJ   Cano Ainara A   Miquilena-Colina María E ME   García-Monzón Carmelo C   Aspichueta Patricia P   Ochoa Begoña B  

Journal of lipid research 20090924 3

We aimed to characterize the primary abnormalities associated with fat accumulation and vulnerability to hepatocellular injury of obesity-related fatty liver. We performed functional analyses and comparative transcriptomics of isolated primary hepatocytes from livers of obese insulin-resistant Zucker rats (comprising mild to severe hepatic steatosis) and age-matched lean littermates, searching for novel genes linked to chronic hepatic steatosis. Of the tested genome, 1.6% was identified as steat  ...[more]

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