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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of A.thaliana to determine the ffect of aneuplody extra copy of chromosome 5

ABSTRACT: Effects of aneuploidy on gene expression in Arabidopsis thaliana containing extra copies of chromosome 5.

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Bruno Huettel

PROVIDER: E-MEXP-1454 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of aneuploidy on genome structure, expression, and interphase organization in Arabidopsis thaliana.

Huettel Bruno B Kreil David P DP Matzke Marjori M Matzke Antonius J M AJ

PLoS genetics 20081017 10

Aneuploidy refers to losses and/or gains of individual chromosomes from the normal chromosome set. The resulting gene dosage imbalance has a noticeable affect on the phenotype, as illustrated by aneuploid syndromes, including Down syndrome in humans, and by human solid tumor cells, which are highly aneuploid. Although the phenotypic manifestations of aneuploidy are usually apparent, information about the underlying alterations in structure, expression, and interphase organization of unbalanced c ...[more]

PMID: 18927630

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