Transcription profiling of liver from wild type or Ercc1 mutant mice

ABSTRACT: The XPF-ERCC1 endonuclease is required for repair of helix-distorting DNA damage and interstrand crosslinks. Here we have engineered a severe mutation in Ercc1 gene (in which the last 7 amino acids are missing; named as "Ercc1-delta") leading to extreme sensitivity to DNA crosslinks and progeria.To investigate whether a disturbance in growth and metabolism could explain the pronounced accelerated organismal deterioration seen in Ercc1 delta mice, we evaluated the liver transcriptome of 16-week-old wt and mutant mice (n=6). At this age, the Ercc1-delta mice have not yet become cachectic.

ORGANISM(S): Mus musculus

SUBMITTER: George Garinis 

PROVIDER: E-MEXP-1503 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress