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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Drosophila wild type, Nurf301 mutant and hop[Tum-1] mutant third instar larvae

ABSTRACT: Expression profile of wild-type and Nurf301 and hop[Tum-l] mutant Drosophila third instar larvae were compared

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Paul Badenhorst

PROVIDER: E-MEXP-1513 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The nucleosome remodeling factor (NURF) regulates genes involved in Drosophila innate immunity.

Kwon So Yeon SY Xiao Hua H Glover Bradley P BP Tjian Robert R Wu Carl C Badenhorst Paul P

Developmental biology 20080212 2

The Drosophila nucleosome remodeling factor (NURF) is an ISWI-containing chromatin remodeling complex that catalyzes ATP-dependent nucleosome sliding. By sliding nucleosomes, NURF has the ability to alter chromatin structure and regulate transcription. Previous studies have shown that mutation of Drosophila NURF induces melanotic tumors, implicating NURF in innate immune function. Here, we show that NURF mutants exhibit identical innate immune responses to gain-of-function mutants in the Drosoph ...[more]

PMID: 18334252

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