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Comparative genomic hybridization of 3 rat strains BN, SS and COP

ABSTRACT: Nimblegen RN34_WG array for BN, SS and COP rats

ORGANISM(S): Rattus norvegicus

SUBMITTER: Victor Guryev 

PROVIDER: E-MEXP-1517 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Mapping of three genetic determinants of susceptibility to estrogen-induced mammary cancer within the Emca8 locus on rat chromosome 5.

Schaffer Beverly S BS   Leland-Wavrin Kristin M KM   Kurz Scott G SG   Colletti John A JA   Seiler Nicole L NL   Warren Christopher L CL   Shull James D JD  

Cancer prevention research (Philadelphia, Pa.) 20121114 1

The ACI rat model of 17β-estradiol (E2)-induced mammary cancer has gained wide use in the study of breast cancer etiology, prevention, and genetics. Emca8, a QTL that determines susceptibility to E2-induced mammary cancer, was previously mapped to rat chromosome 5 (RNO5) in an intercross between resistant Brown Norway (BN) and susceptible ACI rats. In this study, a panel of congenic rat strains, each of which carries BN alleles across a defined segment of RNO5 on the ACI genetic background, was  ...[more]

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