Transcription profiling of human pre and pro B cells from patients with childhood acute lymphoblastic leudemia

ABSTRACT: This data was generated as part of a larger study in to the leukemic stem cell potential of sorted childhood ALL populations. This work has been submitted for publication with the following summary. "We examined the leukemic stem cell potential of blasts at different stages of maturation in childhood acute lymphoblastic leukemia. Human leukemic bone marrow was transplanted intrafemorally onto NOD/scid mice. Cells sorted using the B precursor differentiation markers CD19, CD20 and CD34 were isolated from patient samples and engrafted mice before serial transplantation onto primary or subsequent (up to quaternary) recipients. Surprisingly, blasts representative of all the different maturational stages were able to reconstitute and re-establish the complete leukemic phenotype in vivo. Sorte

ORGANISM(S): Homo sapiens

SUBMITTER: Simon Bomken 

PROVIDER: E-MEXP-1522 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress