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Transcription profiling of human CD4+ T cells induced by HIV-1 gp120/V3 loop peptides, time series

ABSTRACT: Comparative changes of gene expression in human primary CD4+ T cells induced by HIV-1 gp120/V3 loop synthetic peptides, during antigen presentation

ORGANISM(S): Homo sapiens

SUBMITTER: ILIAS KRAMBOVITIS

PROVIDER: E-MEXP-1586 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

The HIV-1 gp120/V3 modifies the response of uninfected CD4 T cells to antigen presentation: mapping of the specific transcriptional signature.

Morou Antigone K AK Porichis Filippos F Krambovitis Elias E Sourvinos George G Spandidos Demetrios A DA Zafiropoulos Alexandros A

Journal of translational medicine 20110924

<h4>Background</h4>The asymptomatic phase of HIV-1 infection is characterized by a progressive depletion of uninfected peripheral effector/memory CD4+ T cells that subsequently leads to immune dysfunction and AIDS symptoms. We have previously demonstrated that the presence of specific gp120/V3 peptides during antigen presentation can modify the activation of normal T-cells leading to altered immune function. The aim of the present study was to map the specific transcriptional profile invoked by ...[more]

PMID: 21943198

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