Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling of mouse CD3e-proficient and deficient thymoma cells

ABSTRACT: Gene expression profiles of CD3e-proficient and CD3e-deficient were analysed using Affymetrix cDNA arrays (MOAE430)

ORGANISM(S): Mus musculus

SUBMITTER: Sabine Herblot

PROVIDER: E-MEXP-1590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

shRNA profiling of human T-ALL cell lines - inhibition of TAL1 and NKX3.1 in T-ALL

Project description:We decreased TAL1 and NKX3.1 proteins levels using lentiviral deliveries of shTAL1 and shNKX3.1 in TAL1 expressing human T-ALL cell lines. Growth curves of cell lines showed that reduced TAL1 and NKX3.1 expressions resulted in a first phase where the number of cells did not increase likewise the shCTL expressing cells. To identify TAL1 and NKX3.1 target genes involved in T-ALL cell growth, we performed gene expression profiling of cell lines expressing shTAL1, shNKX3.1 or shCTL after two and three days of culture. <br><br><br><br>

2010-05-12 | E-MEXP-2197 | biostudies-arrayexpress

Transcription profiling of Medicago sativa MtTTG1 over-expression transgenic alfalfa gene

Project description:Transcriptomics analysis of transgenic alfalfa (TTG1) versus gus control (GUS) in the cultivar R2336.

2009-08-14 | E-MEXP-1759 | biostudies-arrayexpress

Transcription profiling of Medicago trunculata leaf tissue over-expressing Legume Anthocyanin Production

Project description:Transcription profiling of leaf tissue from Medicago truncatula over-expressing Legume Anthocyanin Production.

2009-10-13 | E-MEXP-1854 | biostudies-arrayexpress

Transcription profiling of Medicago sativa leaf tissue in transgenic alfalfa expressing Legume Anthocyanin Production

Project description:Gene expression profiling of leaf tissue in transgenic alfalfa expressing Legume Anthocyanin Production 1.

2009-10-13 | E-MEXP-1855 | biostudies-arrayexpress

RNAi profiling by array of Drosophila salivary glands upon NSL3, MCRS2 and MBDR2 RNAi mediated depletion

Project description:Expression profiling of NSL3, MCRS2 and MBDR2 RNAi-mediated depletion in Drosophila salivary glands. This experiment is related to experiment E-MTAB-214

2010-06-25 | E-MEXP-2652 | biostudies-arrayexpress

Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis in telomerase-proficient mice

Project description:Background and Aims: Telomere dysfunction can increase tumor initiation by induction of chromosomal instability, but initiated tumor cells need to reactivate telomerase for genome stabilization and tumor progression. However, this concept has not been proven in vivo since appropriate mouse models were lacking. Here, we analyzed hepatocarcinogenesis (i) in a novel mouse model of inducible telomere dysfunction on a telomerase-proficient background, (ii) in telomerase knockout mice with chronic telomere dysfunction (G3 mTerc-/-), and (iii) in wild-type mice with functional telomeres and telomerase. Transient or chronic telomere dysfunction enhanced the rates of chromosomal aberrations during hepatocarcinogenesis, but only telomerase-proficient mice exhibited significantly increased rates of macroscopic tumor formation and cancer cell proliferation in response to telomere dysfunction. In contrast, telomere dysfunction resulted in pronounced accumulation of DNA damage, cell cycle arrest and apoptosis in telomerase-deficient liver tumors. Together, these data provide the first in vivo evidence that transient telomere dysfunction during early and late stages of tumorigenesis can promote chromosomal instability and carcinogenesis in telomerase-proficient mice in the absence of additional genetic checkpoint defects at germline level.

2012-03-31 | GSE36813 | GEO

Genome-wide gene expression analysis in ARID1A-proficient and ARID1A-deficient cancer cells

Project description:To investigate that ARID1A regulates transcription of genes encoding components of the GSH synthesis pathway, a genome-wide expression analysis of a panel of ARID1A-proficient and ARID1A-deficient cancer cells was performed.

2019-01-28 | GSE122926 | GEO