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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Pichia pastoris treated with dithiothereitol to induce unfolded protein response

ABSTRACT: Experiment aims to induce unfolded protein response in Pichia pastoris, set-up was chosen to be comparable results to DTT experiment.

ORGANISM(S): Pichia pastoris

SUBMITTER: Alexandra Graf

PROVIDER: E-MEXP-1615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays.

Graf Alexandra A Gasser Brigitte B Dragosits Martin M Sauer Michael M Leparc Germán G GG Tüchler Thomas T Kreil David P DP Mattanovich Diethard D

BMC genomics 20080819

<h4>Background</h4>DNA Microarrays are regarded as a valuable tool for basic and applied research in microbiology. However, for many industrially important microorganisms the lack of commercially available microarrays still hampers physiological research. Exemplarily, our understanding of protein folding and secretion in the yeast Pichia pastoris is presently widely dependent on conclusions drawn from analogies to Saccharomyces cerevisiae. To close this gap for a yeast species employed for its h ...[more]

PMID: 18713468

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