Transcription profiling of skeletal muscle from wild type and mdx mice at three time points

ABSTRACT: In this study, in order to minimize the genetic variability of muscle samples we have used two approaches. First, we have analyzed the gene expression profile from a single skeletal muscle, the medial gastrocnemius (MG), and not from a pool of different muscles which could have different expression profiles. Second, we have performed the temporal gene expression profiling by extracting the MG muscles of the same individual from the both legs at two different times to minimize the inter-individual genetic variability. The MG muscle represent an excellent candidate for biopsy due to its easy accessible by surgery and also because its biopsy is well tolerated by the animals allowing us to perform another later biopsy in the other leg to obtain two MG samples of the same individual at two diff

ORGANISM(S): Mus musculus

DISEASE(S): dystrophic

SUBMITTER: MARIO MAROTTA 

PROVIDER: E-MEXP-1623 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress