Transcription profiling of mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT)

ABSTRACT: Type 2 diabetes is a complex disorder due to defects in insulin secretion and insulin action. Therefore, we investigated mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT) have reduced amount of white adipose tissue, high basal metabolic rate, improved glucose tolerance, high insulin sensitivity, and a low accumulation of triglycerides in liver and skeletal muscle. Our aim was to elucidate the molecular mechanisms leading to the phenotype of SSAT mice.

ORGANISM(S): Mus musculus

SUBMITTER: Joanna Skommer 

PROVIDER: E-MEXP-165 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress