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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse hematopoietic Baf-3 cells inducibly expressing transcription factor Sp1

ABSTRACT: Inducible expression of transcription factor Sp1 in hematopoietic baf-3 cells

ORGANISM(S): Mus musculus

SUBMITTER: Yann LEVERRIER

PROVIDER: E-MEXP-1702 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition.

Deniaud Emmanuelle E Baguet Joël J Chalard Roxane R Blanquier Bariza B Brinza Lilia L Meunier Julien J Michallet Marie-Cécile MC Laugraud Aurélie A Ah-Soon Claudette C Wierinckx Anne A Castellazzi Marc M Lachuer Joël J Gautier Christian C Marvel Jacqueline J Leverrier Yann Y

PloS one 20090915 9

<h4>Background</h4>The ubiquitous transcription factor Sp1 regulates the expression of a vast number of genes involved in many cellular functions ranging from differentiation to proliferation and apoptosis. Sp1 expression levels show a dramatic increase during transformation and this could play a critical role for tumour development or maintenance. Although Sp1 deregulation might be beneficial for tumour cells, its overexpression induces apoptosis of untransformed cells. Here we further characte ...[more]

PMID: 19753117

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