Transcription profiling of mouse spinal cord from mock-infected and Theilers murine encephalomyelitis (TME)-virus infected animals - time series

ABSTRACT: Theiler’s murine encephalomyelitis (TME) is an experimentally virus-induced demyelinating leukomyelitis, displaying clinical and pathological similarities to chronic progressive multiple sclerosis.
The aim of this study was to identify pathways associated with demyelination using an assumption-free microarray approach.
Five-week-old female SJL/JHanHsd-mice were intracerebrally infected with the BeAn-strain of the TME- virus (TMEV) or mock-infected with vehicle only.
Groups of 5-6 TMEV- and Mock-infected mice were killed at 14, 42, 98, and 196 days post infection.
Total RNA was isolated from the spinal cords and gene expression was measured employing Affymetrix mouse genome 430 2.0 arrays.

ORGANISM(S): Mus musculus

SUBMITTER: Reiner Ulrich 

PROVIDER: E-MEXP-1717 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress