Dataset Information
Transcription profiling of male Fech mutant BALB/c mouse livers vs male control BALB/c livers
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
DISEASE(S): porphyria NOS
SUBMITTER: Reginald Davies
PROVIDER: E-MEXP-189 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Hepatic gene expression in protoporphyic Fech mice is associated with cholestatic injury but not a marked depletion of the heme regulatory pool.
The American journal of pathology 20050401 4
BALB/c Fech(m1Pas) mice have a mutated ferrochelatase gene resulting in protoporphyria that models the hepatic injury occurring sporadically in human erythropoietic protoporphyria. We used this mouse model to study the development of the injury and to compare the dysfunction of heme synthesis with hepatic gene expression of liver metabolism, oxidative stress, and cellular injury/inflammation. From an early age expression of total cytochrome P450 and many of its isoforms was significantly lower t ...[more]
