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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Drosophila mechanoreceptor-rich tissue compared mechanoreceptor-poor tissue shows DCX-EMAPis required for mechanoreception in sensory cilia

ABSTRACT: Determining which genes are expressed in mechanoreceptor-rich tissue (pedicel) compared mechanoreceptor-poor tissue (capitellum) and a neuronal subtraction control (thoracic ganglion) in Drosophila melanogaster

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Susanne Bechstedt

PROVIDER: E-MEXP-1921 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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A doublecortin containing microtubule-associated protein is implicated in mechanotransduction in Drosophila sensory cilia.

Bechstedt S S Albert J T JT Kreil D P DP Müller-Reichert T T Göpfert M C MC Howard J J

Nature communications 20100412

Mechanoreceptors are sensory cells that transduce mechanical stimuli into electrical signals and mediate the perception of sound, touch and acceleration. Ciliated mechanoreceptors possess an elaborate microtubule cytoskeleton that facilitates the coupling of external forces to the transduction apparatus. In a screen for genes preferentially expressed in Drosophila campaniform mechanoreceptors, we identified DCX-EMAP, a unique member of the EMAP family (echinoderm-microtubule-associated proteins) ...[more]

PMID: 20975667

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