Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of mouse 3T3-L1 cells before and after adipogenesis

ABSTRACT: Compare miRNA expression profiles between undifferentiated 3T3-L1 preadipocytes (Day 0) and differentiated 3T3-L1 adipocytes (Day 9)

ORGANISM(S): Mus musculus

SUBMITTER: Huangming Xie 

PROVIDER: E-MEXP-1930 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

MicroRNAs induced during adipogenesis that accelerate fat cell development are downregulated in obesity.

Xie Huangming H   Lim Bing B   Lodish Harvey F HF  

Diabetes 20090202 5

<h4>Objective</h4>We investigated the regulation and involvement of microRNAs (miRNAs) in fat cell development and obesity.<h4>Research design and methods</h4>Using miRNA microarrays, we profiled the expression of >370 miRNAs during adipogenesis of preadipocyte 3T3-L1 cells and adipocytes from leptin deficient ob/ob and diet-induced obese mice. Changes in key miRNAs were validated by RT-PCR. We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to t  ...[more]