Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of pancreatic islets from heterozygous Hnf1a-mutant and wild type mice


ABSTRACT: Pancreatic islets were isolated from Hnf1a+/- (Hepatocyte nuclear factor 1 alpha) and wild-type mice and cultured ex vivo for two days in RPMI medium with 10% FBS before RNA extraction. The transcription profiles were obtained using Affymetrix GeneChip Mouse Genome 430 2.0 arrays [Mouse430_2].

ORGANISM(S): Mus musculus

SUBMITTER: Joan-Marc Servitja 

PROVIDER: E-MEXP-1979 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Hnf1alpha (MODY3) controls tissue-specific transcriptional programs and exerts opposed effects on cell growth in pancreatic islets and liver.

Servitja Joan-Marc JM   Pignatelli Miguel M   Maestro Miguel Angel MA   Cardalda Carina C   Boj Sylvia F SF   Lozano Juanjo J   Blanco Enrique E   Lafuente Amàlia A   McCarthy Mark I MI   Sumoy Lauro L   Guigó Roderic R   Ferrer Jorge J  

Molecular and cellular biology 20090316 11


Heterozygous HNF1A mutations cause pancreatic-islet beta-cell dysfunction and monogenic diabetes (MODY3). Hnf1alpha is known to regulate numerous hepatic genes, yet knowledge of its function in pancreatic islets is more limited. We now show that Hnf1a deficiency in mice leads to highly tissue-specific changes in the expression of genes involved in key functions of both islets and liver. To gain insights into the mechanisms of tissue-specific Hnf1alpha regulation, we integrated expression studies  ...[more]

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