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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of prostates from normal and Pten knock-out mice, and comparing the gene expression profile in the proximal and distal part of normal prostates

ABSTRACT: 1. Comparison of gene expression profiles of normal prostates and prostates isolated from 4-5 months old PSA-Cre;Pten-loxP/loxP mice
2.Comparison of the gene expression profile in the proximal and distal part of normal prostates

ORGANISM(S): Mus musculus

DISEASE(S): normal

SUBMITTER: Hanneke Korsten

PROVIDER: E-MEXP-2029 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Accumulating progenitor cells in the luminal epithelial cell layer are candidate tumor initiating cells in a Pten knockout mouse prostate cancer model.

Korsten Hanneke H Ziel-van der Made Angelique A Ma Xiaoqian X van der Kwast Theo T Trapman Jan J

PloS one 20090522 5

The PSA-Cre;Pten-loxP/loxP mouse prostate cancer model displays clearly defined stages of hyperplasia and cancer. Here, the initial stages of hyperplasia development are studied. Immunohistochemical staining showed that accumulated pAkt+ hyperplastic cells overexpress luminal epithelial cell marker CK8, and progenitor cell markers CK19 and Sca-1, but not basal epithelial cell markers. By expression profiling we identified novel hyperplastic cell markers, including Tacstd2 and Clu. Further we sho ...[more]

PMID: 19461893

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