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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human blood taken from individuals fed an antioxidant-rich diet or a diet containing kiwi-fruit to evaluate the effect on gene expression with emphasis on stress and repair related processes

ABSTRACT: Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases such as cancer and cardiovascular diseases. The mechanisms behind this protective effect is not elucidated. We have studied whether a specially designed antioxidant-rich food diet and a kiwi-fruit intervention can affect whole genome expression in human blood cells with emphasis on stress and repair related process.

ORGANISM(S): Homo sapiens

SUBMITTER: Siv Kj?lsrud B?hn

PROVIDER: E-MEXP-2030 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers.

Bøhn Siv K SK Myhrstad Mari C MC Thoresen Magne M Holden Marit M Karlsen Anette A Tunheim Siv Haugen SH Erlund Iris I Svendsen Mette M Seljeflot Ingebjørg I Moskaug Jan O JO Duttaroy Asim K AK Laake Petter P Arnesen Harald H Tonstad Serena S Collins Andrew A Drevon Christan A CA Blomhoff Rune R

BMC medicine 20100916

<h4>Background</h4>Plant-based diets rich in fruit and vegetables can prevent development of several chronic age-related diseases. However, the mechanisms behind this protective effect are not elucidated. We have tested the hypothesis that intake of antioxidant-rich foods can affect groups of genes associated with cellular stress defence in human blood cells.<h4>Trial registration number</h4>NCT00520819 http://clinicaltrials.gov.<h4>Methods</h4>In an 8-week dietary intervention study, 102 health ...[more]

PMID: 20846424

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