Dataset Information
MicroRNA profiling of human TIG3 TERT/deltaB-RAF ER cells treated with 4-hydroxytamoxifen
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mikkel Klausen
PROVIDER: E-MEXP-2038 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.
Cell death and differentiation 20090821 2
Aberrant oncogene activation induces cellular senescence, an irreversible growth arrest that acts as a barrier against tumorigenesis. To identify microRNAs (miRNAs) involved in oncogene-induced senescence, we examined the expression of miRNAs in primary human TIG3 fibroblasts after constitutive activation of B-RAF. Among the regulated miRNAs, both miR-34a and miR-146a were strongly induced during senescence. Although members of the miR-34 family are known to be transcriptionally regulated by p53 ...[more]
