MicroRNA profiling of human colon cancer cell lines from the primary lesion and lymph node metastatis of the same patient

ABSTRACT: Two colon cancer cell lines, SW480 and SW620, were originated from the same patient. The SW480 cell line was derived from a primary lesion, and the SW620 cell line was cultured from a lymph node metastasis with no intervening chemotherapy at a later time. Since these two cell lines are from a single person, it is likely that differences between the two cell lines represent the changes when cancer cells acquire metastatic potential. Thus, this system represents a perfect model for the study of metastatic mechanism. To investigate cancer metastasis associated miRNAs, we detected the miRNA profiles in these two cell lines.

ORGANISM(S): Homo sapiens

SUBMITTER: Tao Liu 

PROVIDER: E-MEXP-2060 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress