Transcription profiling of Leishmania infantum, Leishmania major, Leishmania braziliensis intracellular amastigotes shows low level modulation between species and in different host genetic backgrounds

ABSTRACT: Genome sequencing of species of the kinetoplastid parasite, Leishmania, that give rise to a range of disease phenotypes in the host has revealed highly conserved gene content and synteny across the genus. Only a small number of genes are differentially distributed between the three species studied to date, L. major, L. infantum and L. braziliensis. Here, we focus on RNA expression in the disease-promoting intracellular amastigotes and use customised oligonucleotide microarrays to confirm that all of these differentially-distributed genes are expressed in this critical stage of the parasite life cycle, with only a few regulated between species.

ORGANISM(S): Leishmania braziliensis

DISEASE(S): N/A (culture-derived)

SUBMITTER: Deborah Smith 

PROVIDER: E-MEXP-2063 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress