Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Streptomyces coelicolor wild type and delta0877 and delta7173 mutant strains

ABSTRACT: Gene expression analysis of S. coelicolor M145 wild type strain, and mutants delta0877 and delta 7173. RNA samples were extracted from 48 h culture samples during growth in flasks in defined mineral medium MG supplemented with 5% of yeast extract. Cy5 labelled genomic DNA was used as the common reference.

ORGANISM(S): Streptomyces coelicolor

SUBMITTER: Antonio RodrM-mguez-GarcM-ma 

PROVIDER: E-MEXP-2132 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

LAL regulators SCO0877 and SCO7173 as pleiotropic modulators of phosphate starvation response and actinorhodin biosynthesis in Streptomyces coelicolor.

Guerra Susana M SM   Rodríguez-García Antonio A   Santos-Aberturas Javier J   Vicente Cláudia M CM   Payero Tamara D TD   Martín Juan F JF   Aparicio Jesús F JF  

PloS one 20120220 2

LAL regulators (Large ATP-binding regulators of the LuxR family) constitute a poorly studied family of transcriptional regulators. Several regulators of this class have been identified in antibiotic and other secondary metabolite gene clusters from actinomycetes, thus they have been considered pathway-specific regulators. In this study we have obtained two disruption mutants of LAL genes from S. coelicolor (Δ0877 and Δ7173). Both mutants were deficient in the production of the polyketide antibio  ...[more]

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