Transcription profiling of human HUVEC cells with internalised S. aureus

ABSTRACT: Staphylococcus aureus is a Gram-positive bacteria frequently isolated from patients with bloodstream infections. Endothelial cells (ECs) play an important role in host cell defence against bacteria, and recent reports have shown that infection of ECs with S. aureus induces a wide range of cytokines and cell surface receptors involved in activating the innate immune response (). The ability of S. aureus to invade nonphagocytic cells, including ECs, has been documented (), however, the knowledge of ECs role in pathogenesis of S. aureus infection is still limited.
In this study, we investigate the gene expression program initiated in human ECs by internalized S. aureus, using microarray analysis. We found 156 genes differentially regulated at least threefold, using arrays representing 1

ORGANISM(S): Homo sapiens

SUBMITTER: Robert Geffers 

PROVIDER: E-MEXP-226 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress