Transcription profiling of human vascular smooth muscle cells treated with glucose oxidase and human haemoglogib reveals ferrous hemoglobin can protect vascular smooth muscle cells from hydrogen peroxide-induced oxidative stress response and cell damage

ABSTRACT: Hemoglobin (Hb) is released from red blood cells (RBC) during intravascular hemolysis. Cell free Hb has been implicated to play a pathogenic role in hemolytic diseases such as sickle cell anemia or malaria. Hydrogen peroxide (H2O2) is the most prevalent reactive oxygen species which is produced in excess during inflammation or tissue injury and has been included as a potential mediator of oxidative stress related cell and tissue damage. The biologic significance of Hb’s peroxidase activity as an anti-oxidant is controversial as the radicals and higher oxidation iron species which are potentially released during these reactions could be a source of exaggerated oxidative damage. Using a cell culture model of low-flux continuous H2O2 generation by glucose-oxidase (GOx) Hb revealed the potenti

ORGANISM(S): Homo sapiens

SUBMITTER: Corinne Widmer 

PROVIDER: E-MEXP-2263 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress