Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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MicroRNA profiling of mouse mammary tumor cell lines with different metastatic abilities

ABSTRACT: Compare miRNA expression profiles in isogenic mouse mammary tumor cell lines (67NR, 168FARN, 4TO7, 4T1) with different metastatic abilities

ORGANISM(S): Mus musculus

SUBMITTER: Huangming Xie 

PROVIDER: E-MEXP-2289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

miR-200 enhances mouse breast cancer cell colonization to form distant metastases.

Dykxhoorn Derek M DM   Wu Yichao Y   Xie Huangming H   Yu Fengyan F   Lal Ashish A   Petrocca Fabio F   Martinvalet Denis D   Song Erwei E   Lim Bing B   Lieberman Judy J  

PloS one 20090929 9

<h4>Background</h4>The development of metastases involves the dissociation of cells from the primary tumor to penetrate the basement membrane, invade and then exit the vasculature to seed, and colonize distant tissues. The last step, establishment of macroscopic tumors at distant sites, is the least well understood. Four isogenic mouse breast cancer cell lines (67NR, 168FARN, 4TO7, and 4T1) that differ in their ability to metastasize when implanted into the mammary fat pad are used to model the  ...[more]

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