Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse aorta and vSMCs response to dioxin

ABSTRACT: We compared the global gene expression profiles of C57BL/6 mice aortas with the profiles of cultured vascular smooth muscle cells (vSMC) from the same mice, and determined whether gene responses to dioxin exposure in the vSMCs would be predictive of responses in the aorta.

ORGANISM(S): Mus musculus

SUBMITTER: Alvaro Puga 

PROVIDER: E-MEXP-23 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiles of mouse aorta and cultured vascular smooth muscle cells differ widely, yet show common responses to dioxin exposure.

Puga Alvaro A   Sartor Maureen A MA   Huang Ming-Ya MY   Kerzee J Kevin JK   Wei Yu-Dan YD   Tomlinson Craig R CR   Baxter C Stuart CS   Medvedovic Mario M  

Cardiovascular toxicology 20040101 4

Exposure to environmental toxicants may play a role in the onset and progression of cardiovascular disease. Many environmental agents, such as dioxin, are risk factors for atherosclerosis because they may exacerbate an underlying disease by altering gene expression patterns. Expression profiling of vascular tissues allows the simultaneous analysis of thousands of genes and may provide predictive information particularly useful in early disease stages. Often, however, in vivo experiments are unfe  ...[more]

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