MiRNA profiling of human prostate cancer cell lines treated with 5azadC and TSA to investigate epigenetic modifications

ABSTRACT: miRNA expression profiling of prostate cancer cell lines, PC-3, DU145, LAPC-4, VCaP, LNCaP, 22rv1, and normal prostate epithelial cells, PrECs, was done after treating the cells with DNA demethylating agent 5-aza-2'-deoxycytidine (5azadC; Sigma-Aldrich, St. Louis, MO) and histone deacetylase inhibitor trichostatin A (TSA; Sigma-Aldrich). These treatments relieve epigenetic modifications, and thus reveal potentially epigenetically silenced miRNAs amongst the miRNAs with increased expression after the treatments.

ORGANISM(S): Homo sapiens

DISEASE(S): prostate carcinoma

SUBMITTER: Hanna Rauhala 

PROVIDER: E-MEXP-2313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress