Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

Transcription profiling of human SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue

ABSTRACT: Gene expression profiling of SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue.

ORGANISM(S): Homo sapiens

SUBMITTER: Jakub Mieczkowski

PROVIDER: E-MEXP-2351 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications.

Tyburczy Magdalena Ewa ME Kotulska Katarzyna K Pokarowski Piotr P Mieczkowski Jakub J Kucharska Joanna J Grajkowska Wieslawa W Roszkowski Maciej M Jozwiak Sergiusz S Kaminska Bozena B

The American journal of pathology 20100204 4

Subependymal giant cell astrocytomas (SEGAs) are rare brain tumors associated with tuberous sclerosis complex (TSC), a disease caused by mutations in TSC1 or TSC2, resulting in enhancement of mammalian target of rapamycin (mTOR) activity, dysregulation of cell growth, and tumorigenesis. Signaling via mTOR plays a role in multifaceted genomic responses, but its effectors in the brain are largely unknown. Therefore, gene expression profiling on four SEGAs was performed with Affymetrix Human Genome ...[more]

PMID: 20133820

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Dataset Information

Transcription profiling of human SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue

Publications

Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications.

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