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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse SNF5 liver-specific inactivation in SNF5 flox/knockouts

ABSTRACT: Effect of liver-specific inactivation of SNF5 on liver transcriptome. Comparison of control and mutant livers.

ORGANISM(S): Mus musculus

SUBMITTER: Moshe Yaniv

PROVIDER: E-MEXP-241 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation.

Gresh Lionel L Bourachot Brigitte B Reimann Andreas A Guigas Bruno B Fiette Laurence L Garbay Serge S Muchardt Christian C Hue Louis L Pontoglio Marco M Yaniv Moshe M Klochendler-Yeivin Agnès A

The EMBO journal 20050901 18

Regulation of gene expression underlies cell differentiation and organogenesis. Both transcription factors and chromatin modifiers are crucial for this process. To study the role of the ATP-dependent SWI/SNF chromatin-remodeling complex in cell differentiation, we inactivated the gene encoding the core complex subunit SNF5/INI1 in the developing liver. Hepatic SNF5 deletion caused neonatal death due to severe hypoglycemia; mutant animals fail to store glycogen and have impaired energetic metabol ...[more]

PMID: 16138077

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