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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of 3 mouse cell lines infected with Leishmania

ABSTRACT: Gene expression levels in 14M1.4, MBA-1 and RAW264.7 cells, we performed genome wide expression analysis using the GeneChip Mouse Genome 430 2.0 array (Affymetrix). Control or infected MBA-1 and RAW264.7 cells were incubated for 12 and 48 hours before RNA extraction.

ORGANISM(S): Mus musculus

SUBMITTER: Naveed Aziz

PROVIDER: E-MEXP-2554 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Stromal cell-derived CXCL12 and CCL8 cooperate to support increased development of regulatory dendritic cells following Leishmania infection.

Nguyen Hoang Anh Thu AT Liu Hao H Juaréz Julius J Aziz Naveed N Kaye Paul M PM Svensson Mattias M

Journal of immunology (Baltimore, Md. : 1950) 20100712 4

In the immune system, stromal cells provide specialized niches that control hematopoiesis by coordinating the production of chemokines, adhesion molecules, and growth factors. Stromal cells also have anti-inflammatory effects, including support for the differentiation of hematopoietic progenitors into dendritic cells (DCs) with immune regulatory properties. Together, these observations suggest that the alterations in hematopoiesis commonly seen in infectious disease models, such as experimental ...[more]

PMID: 20624948

Publication: 1/2

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