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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human H1299 cells and Saos-2 cells (p53 null cells) transfected with Flag vector, Flag-p53 WT or Flag-p53 SA

ABSTRACT: H1299 cells and Saos-2 cells (p53 null cells) were transfected with Flag vector, Flag-p53 WT or Flag-p53 SA.

ORGANISM(S): Homo sapiens

SUBMITTER: Junko Kimura

PROVIDER: E-MEXP-2556 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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D4S234E, a novel p53-responsive gene, induces apoptosis in response to DNA damage.

Kudoh Takuya T Kimura Junko J Lu Zheng-Guang ZG Miki Yoshio Y Yoshida Kiyotsugu K

Experimental cell research 20100701 17

Understanding intracellular transduction pathways on apoptosis is indispensable for clinical application to develop effective cancer therapies. Transcription factor p53 is activated in response to genotoxic damage and plays crucial roles in apoptosis. p53 regulates the expression of numerous apoptosis-related genes to induce cell death. Here, through genome-wide comprehensive gene expression profile, we identified D4S234E as a novel p53-responsive gene. We determined the p53-binding region in th ...[more]

PMID: 20599942

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