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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human colon cancer cell line SW620 treated wit tetradecylthioacetic acid (TTA) or control (NaOH).

ABSTRACT: Adenocarcinoma cell line SW620 were treated with tetradecylthioacetic acid,TTA, or control (NaOH) for 24 h. degrees RNA isolated, Affymetrix gene expression

ORGANISM(S): Homo sapiens

SUBMITTER: Caroline Pettersen

PROVIDER: E-MEXP-2590 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Tetradecylthioacetic acid inhibits proliferation of human SW620 colon cancer cells--gene expression profiling implies endoplasmic reticulum stress.

Lundemo Anne G AG Pettersen Caroline H H CH Berge Kjetil K Berge Rolf K RK Schønberg Svanhild A SA

Lipids in health and disease 20111025

<h4>Background</h4>Previous reports have shown an antiproliferative effect of the synthetic, 3-thia fatty acid tetradecylthioacetic acid (TTA) on different cancer cells in vitro and in vivo. The mechanisms behind the observed effects are poorly understood. We therefore wanted to explore the molecular mechanisms involved in TTA-induced growth inhibition of the human colon cancer cell line SW620 by gene expression profiling.<h4>Methods</h4>An antiproliferative effect of TTA on SW620 cells in vitro ...[more]

PMID: 22027281

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