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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of mouse liver after peroral infection Ehinococcus multilocularis eggs

ABSTRACT: We used a mouse model of alveolar echinococcosis to assess gene expression profiles in the liver after establishment of a chronic disease status as a result of a primary peroral infection with eggs of the fox tapeworm Echinococcus multilocularis.

ORGANISM(S): Mus musculus

SUBMITTER: Matthias Wittwer

PROVIDER: E-MEXP-2615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Hepatic gene expression profile in mice perorally infected with Echinococcus multilocularis eggs.

Gottstein Bruno B Wittwer Matthias M Schild Marc M Merli Michael M Leib Stephen L SL Müller Norbert N Müller Joachim J Jaggi Rolf R

PloS one 20100401 4

<h4>Background</h4>Alveolar echinococcosis (AE) is a severe chronic hepatic parasitic disease currently emerging in central and eastern Europe. Untreated AE presents a high mortality (>90%) due to a severe hepatic destruction as a result of parasitic metacestode proliferation which behaves like a malignant tumor. Despite this severe course and outcome of disease, the genetic program that regulates the host response leading to organ damage as a consequence of hepatic alveolar echinococcosis is la ...[more]

PMID: 20368974

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