Transcription profiling by array of human astrocytes derived from trisomic human embryonic stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): normal
SUBMITTER: Sailesh Gopalakrishna-Pillai
PROVIDER: E-MEXP-2633 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Astrocytes derived from trisomic human embryonic stem cells express markers of astrocytic cancer cells and premalignant stem-like progenitors.
Gopalakrishna-Pillai Sailesh S Iverson Linda E LE
BMC medical genomics 20100427
<h4>Background</h4>Trisomic variants of human embryonic stem cells (hESCs) arise spontaneously in culture. Although trisomic hESCs share many properties with diploid hESCs, they also exhibit features of cancer stem cells. Since most hESC-based therapies will utilize differentiated derivatives, it is imperative to investigate the potential of trisomic hESCs to undergo malignant transformation during differentiation prior to their use in the clinical setting.<h4>Methods</h4>Diploid and trisomic hE ...[more]
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