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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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ChIP-chip by array of mouse 416Bcell line using anti-PU.1 (Santa Cruz, sc-352X).

ABSTRACT: Immunoprecipitations were performed using anti-PU.1 (Santa Cruz, sc-352X)

ORGANISM(S): Mus musculus

SUBMITTER: Fernando Calero-Nieto

PROVIDER: E-MEXP-2666 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Transcriptional regulation of Elf-1: locus-wide analysis reveals four distinct promoters, a tissue-specific enhancer, control by PU.1 and the importance of Elf-1 downregulation for erythroid maturation.

Calero-Nieto Fernando J FJ Wood Andrew D AD Wilson Nicola K NK Kinston Sarah S Landry Josette-Renée JR Göttgens Berthold B

Nucleic acids research 20100604 19

Ets transcription factors play important roles during the development and maintenance of the haematopoietic system. One such factor, Elf-1 (E74-like factor 1) controls the expression of multiple essential haematopoietic regulators including Scl/Tal1, Lmo2 and PU.1. However, to integrate Elf-1 into the wider regulatory hierarchies controlling haematopoietic development and differentiation, regulatory elements as well as upstream regulators of Elf-1 need to be identified. Here, we have used locus- ...[more]

PMID: 20525788

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