Browse
Submit Data
Databases
API
Help

Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

3 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcription profiling by array of human fetuses with polymalformative syndrome and KIF7 mutations

ABSTRACT: We identified KIF7, a major actor of Shh pathway as the responsible gene for a polymalformative syndrome in 3 siblings born from consanguinous parents.
In order to study the expression of Shh pathway actors and to identify deregulation in expression of targets of the pathway, we performed microarray expression analysis with RNA extracted from pulmonary tissues from three mutated fetuses and from three age-match controls

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Tania Attié-Bitach

PROVIDER: E-MEXP-2707 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Similar Datasets

Transcription profiling of Danio rerio (zebrafish) RPL11 mutant vs siblings

Project description:Transcriptional profile of RPL11 zebrafish mutant in comparison to siblings

2010-01-01 | E-MEXP-2381 | biostudies-arrayexpress

Transcription profiling by array of rat cerebellar granular neuronal precursor cells plated with Sonic Hedgehog (Shh) and then treated with the PKA activator DBA

Project description:Cerebellar granular neuronal precursors were plated in presence of Sonic Hedgehog (Shh) for 24h and then treated with the PKA activator Dibutyryl Cyclic Adenosine Monophosphate (DBA) for addittional 24h

2008-07-11 | E-MEXP-1668 | biostudies-arrayexpress

Transcription profiling of zebrafish cls/sox10 mutants at 4dpf compared to their wild type siblings at 4 day identifies lndc1 as a novel factor in Schwann cell development

Project description:Transcription profile of cls/sox10 mutants at 4dpf compared to their wild type siblings at 4 days post fertilization. Transcription profile of hps/erbb3b mutants compared to a wild type control at 4 days post fertilization.

2009-12-15 | E-MEXP-2215 | biostudies-arrayexpress

Transcription profiling of rat cerebellar granular cells cultured in the presence of Shh for 24h and then pulsed with Bmp2 or vehicle for up to 24h

Project description:Proliferating cerebellar granular cells were cultured in presence of Shh for 24h (3ug/ml) and then pulsed for additional 24h with Bmp2 or vehicle. Cells then were lysed and mRNA extracted. Microarray data from cells treated with Bmp2 was referred to the control not treated with Bmp2.

2007-06-07 | E-MEXP-1129 | biostudies-arrayexpress

Transcription profiling of human fibroblasts from the skin of cocoon affected fetuses and healthy controls

Project description:Comparison of the transcriptome and differences in it between cocoon affected cases and healthy controls.

2011-03-10 | E-MEXP-2143 | biostudies-arrayexpress

Transcription profiling of zebrafish mutants affected in neural crest development

Project description:Mutants of zebrafish affected in neural crest development (cls/sox10, hps/erbb3, low/tfap2a, nac/mitfa, pfe/csfr1, shd/ltk, spa/kit tdo/trpm7) were compared to their wild type siblings or to wild type controls during development at 28hpf, 48hpf and 4 dpf.

2012-06-05 | E-TABM-748 | biostudies-arrayexpress

Transcription profiling of Arabidopsis Umkirch-1/Umkirch-3 hybrid plants compared to siblings carrying a microRNA targeting the Umkirch-3 allele of At5g41750

Project description:Umkirch-1/Umkirch-3 hybrid plants (KB142-2) grown at 16 degreeC long day were compared with siblings carrying a microRNA targeting the Umkirch-3 allele of At5g41750. Plants were about 3 weeks old, and whole rosettes were harvested. Each sample is a pool of 8-10 individuals.

2007-07-11 | E-ATMX-26 | biostudies-arrayexpress

Transcription profiling by array of human skin fibroblasts from fetuses with hydrolethalus syndrome and healthly controls

Project description:Comparison of the transcriptome and differences in it between cases (hydrolethalus syndrome) and healthy controls

2009-05-19 | E-MEXP-1900 | biostudies-arrayexpress

Transcription profiling of rat neonatal spinal cord reveals two distinct neuronal populations

Project description:Here we compare the gene expression profiles of two distict, fluorescently identified neuronal populations, the motor neruons (MN) and the decending commissural interneurons (dCIN) of the neonatal rat spinal cord isolated with laser microdissection. These two populations participate in the neuronal networks in the spinal cord where they have destinct functions in shaping (dCINs) and transferring the output to the muscles (MNs) during locomotion. We wished to determine how the functinal differences in these nerurons are manifested at the gene expression level. Experiment Overall Design: Neurons were retrogradely labelled with rhodamine through application of the tracer to cut axons followed by incubation in oxygenated Ringer solution. Spinal cord were then snap frozen, cryosectioned and fluorescent single cells were laser dissected into a collector tube to a total of ca. 50-200 cells pr sample. RNA was then extracted, two round amplified and hybridized to Affymatrix RNU-34 chips. 22 samples were hybridized onto chips, 7 MNs, 7 CINS and 8 MIX.

2008-06-16 | E-GEOD-9439 | biostudies-arrayexpress

Genome-wide analysis of Gata3 [ChIP-seq and RNA-seq]

Project description:Shh and its receptor Ptch1 define two adjacent mutually exclusive domains: Shh+Ptch1- and Shh-Ptch1+ of E11.5 mouse brain. Gata3 ChIP-seq experiments and RNA-seq assays on Gata3-knockdown cells revealed that Gata3 up-regulates genes enriched in Shh-Ptch1+ domain. Our work is the first genome-wide characterization of gene regulatory mechanisms in Shh pathway underlying the pattern formation of early mouse brain.

2013-11-30 | E-MTAB-2008 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data