Transcription profiling of human cells line with different D10 values to assay radiosensitivity
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
DISEASE(S): adenocarcinoma
SUBMITTER: Atsuko Ishikawa
PROVIDER: E-MEXP-272 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Gene expression profile changes correlating with radioresistance in human cell lines.
Ishikawa Ken-ichi K Koyama-Saegusa Kumiko K Otsuka Yoshimi Y Ishikawa Atsuko A Kawai Seiko S Yasuda Kaori K Suga Tomo T Michikawa Yuichi Y Suzuki Masao M Iwakawa Mayumi M Imai Takashi T
International journal of radiation oncology, biology, physics 20060501 1
<h4>Purpose</h4>To identify gene expression profiles specific to radioresistance of human cells.<h4>Methods and materials</h4>Global gene expression profiles of a total of 15 tumor and normal fibroblast cell lines were analyzed using DNA microarrays and statistical clustering methods. Initially, six of the cell lines were categorized into radioresistant (RG) or nonradioresistant (NRG) groups according to the radiation dose required to reduce their survival to 10% (D10). Genes for which expressio ...[more]
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