Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of yeast wild type and Δhaa1 deletion mutants following acetic acid stress

ABSTRACT: The experiment describes the transcriptional response of Saccharomyces cerevisiae BY4741 and of the deletion mutant Δhaa1 following an incubation in the presence of 50 mM acetic acid (at pH 4.0)

ORGANISM(S): Saccharomyces cerevisiae

SUBMITTER: Nuno Mira 

PROVIDER: E-MEXP-2740 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genomic expression program involving the Haa1p-regulon in Saccharomyces cerevisiae response to acetic acid.

Mira Nuno P NP   Becker Jorg D JD   Sá-Correia Isabel I  

Omics : a journal of integrative biology 20101001 5

The alterations occurring in yeast genomic expression during early response to acetic acid and the involvement of the transcription factor Haa1p in this transcriptional reprogramming are described in this study. Haa1p was found to regulate, directly or indirectly, the transcription of approximately 80% of the acetic acid-activated genes, suggesting that Haa1p is the main player in the control of yeast response to this weak acid. The genes identified in this work as being activated in response to  ...[more]

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