Transcriptional profiling of neoplastically transformed and wild type wing imaginal discs of Drosophila

ABSTRACT: In Drosophila, homozygosity for tumor suppressors, like lethal giant larvae, lgl, results in neoplastic transformation of imaginal disc epithelium - characterized by loss of their apico-basal polarity, unrestricted growth and invasion into neighboring tissues/organs. In genetic mosaics, however, lgl mutant clones are eliminated shortly after their initiation by cell competition. On the other hand, lgl mutant clones generated in Minute (M) genetic background, which compromises cell competition from the neighboring wild type cells, display clonal progression and tissue invasion. To gain insight into the molecular players of fly tumorigensis we undertook genome-wide transcriptional profiling of neoplastically transformed mosaic wing imaginal discs where lgl- clones were induced in M genetic b

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ram Gupta 

PROVIDER: E-MEXP-2753 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress