RNAi profiling by array of human WPMY-1 cells with PPARbeta/delta knock down and exposure to PPAR agaonists
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Florian Finkernagel
PROVIDER: E-MEXP-2756 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Genomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ).
Adhikary Till T Kaddatz Kerstin K Finkernagel Florian F Schönbauer Anne A Meissner Wolfgang W Scharfe Maren M Jarek Michael M Blöcker Helmut H Müller-Brüsselbach Sabine S Müller Rolf R
PloS one 20110119 1
Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors with essential functions in lipid, glucose and energy homeostasis, cell differentiation, inflammation and metabolic disorders, and represent important drug targets. PPARs heterodimerize with retinoid X receptors (RXRs) and can form transcriptional activator or repressor complexes at specific DNA elements (PPREs). It is believed that the decision between repression and activation is generally governed by a ligand-mediated s ...[more]
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