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Transcription profiling by array of Drosophila dAda2a amd dAda3 mutants at the puparium formation stage

ABSTRACT: Analyze the Drosophila ATAC complex function at the puparium formation stage. dAda2a and dAda3 were used.

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Tibor Pankotai

PROVIDER: E-MEXP-2765 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Genes of the ecdysone biosynthesis pathway are regulated by the dATAC histone acetyltransferase complex in Drosophila.

Pankotai T T Popescu C C Martín D D Grau B B Zsindely N N Bodai L L Tora L L Ferrús A A Boros I I

Molecular and cellular biology 20100628 17

Uncovering mechanisms that regulate ecdysone production is an important step toward understanding the regulation of insect metamorphosis and processes in steroid-related pathologies. We report here the transcriptome analysis of Drosophila melanogaster dAda2a and dAda3 mutants, in which subunits of the ATAC acetyltransferase complex are affected. In agreement with the fact that these mutations lead to lethality at the start of metamorphosis, both the ecdysone levels and the ecdysone receptor bind ...[more]

PMID: 20584983

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