Transcription profiling by array of heart tissue from rats kept in normoxic or hypoxic conditions

ABSTRACT: Animal models of right ventricular hypertrophy. 48 male Wistar rats (10 weeks, weight approximately 290 grams) were divided into two groups of 24 animals. Each group was divided into subgroups of six animals. Four subgroups were maintained at hypobaric, hypoxic pressure. Four subgroups were maintained at normobaric, normoxic pressure and served as controls. The hypoxic group was placed in a hypobaric chamber, where the ambient pressure was continuously held at 500 mbar which created an oxygen tension of 10%. The temperature in the chamber was maintained at 21-22oC and the chamber was ventilated with air at approximately 45 min-1 through an inlet valve with the aid of a vacuum pump. The four subgroups were maintained in these hypoxic, hypobaric conditions for 1, 2, 3 or 4 weeks and studied

ORGANISM(S): Rattus norvegicus

SUBMITTER: Nils Magnusson 

PROVIDER: E-MEXP-2863 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress