Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling by array of human CD19+CD127+ and CD19+CD127- B cell populations derived from neonatal cord blood CD34+ cells

ABSTRACT: We derived B-lineage cells by in vitro culture of neonatal cord blood CD34+ cells on MS-5 stromal cells with recombinant IL-7. These cultures yielded CD19+CD127+ and CD19+CD127- cell populations. We performed gene expression profiling on these populations and compared these with each other and with published expression profiles of freshly isolated BM precursor B-cell subsets (E-MEXP-384). These analyses yielded new insights into their different functionality and developmental stage.

A file containing statistical analysis of the normalized data is included in the file named E-MEXP-2878.additional.zip on the FTP site for this experiment.

ORGANISM(S): Homo sapiens

SUBMITTER: Menno van Zelm

PROVIDER: E-MEXP-2878 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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