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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mouse wild type adult male mouse livers vs transgenic mice expressing human Small Heterodimer Partner in hepatocytes

ABSTRACT: Comparison of gene expression in adult male mouse livers between wildtype mice and Transgenic mice expressing human Small Heterodimer Partner in hepatocytes.

ORGANISM(S): Mus musculus

SUBMITTER: Peter Underhill

PROVIDER: E-MEXP-294 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Regulation of hepatic metabolic pathways by the orphan nuclear receptor SHP.

Boulias Konstantinos K Katrakili Nitsa N Bamberg Krister K Underhill Peter P Greenfield Andy A Talianidis Iannis I

The EMBO journal 20050623 14

SHP (small heterodimer partner) is an important component of the feedback regulatory cascade, which controls the conversion of cholesterol to bile acids. In order to identify the bona fide molecular targets of SHP, we performed global gene expression profiling combined with chromatin immunoprecipitation assays in transgenic mice constitutively expressing SHP in the liver. We demonstrate that SHP affects genes involved in diverse biological pathways, and in particular, several key genes involved ...[more]

PMID: 15973435

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